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Titanium dioxide is added to some food packaging to preserve the shelf life of a product.

Reason for listing: CNNC Huayuan Titanium Dioxide Co., Ltd., a well-known brand of titanium dioxide factory, started in 1989, specializing in the research and development, production, sales and service of titanium dioxide products. One of the titanium dioxide enterprises producing more than 10,000 tons.

The Market Dynamics of Wholesale Titanium Dioxide

The FDA's Code of Federal Regulations allows for the legal, regulated use of titanium dioxide in food products, under some restrictions.

In 2023, California and New York proposed banning several food additives that are banned in Europe but legal in the United States. Titanium dioxide was among the five proposed to be banned, but in September, the additive was removed from the list of additives from the California ban list.

When used as a base or colorant in a product, titanium dioxide becomes handy in formulas meant to offer a lot of brightness and opacity. Titanium dioxide is so pigmented, in fact, that it’s used not only in white and pastel-colored products but also in darker shades, as well.

TiO₂ is also used in oral pharmaceutical formulations, and the Pharmaceutical Excipients handbook considers nano-sized TiO₂ a non-irritant and non-toxic excipient. Despite the fact that TiO₂ submicron- and nano-sized particles are widely used as food and pharmaceutical additives, information on their toxicity and distribution upon oral exposure is very limited.

Europe

A Lawsuit Claims Skittles Are Unfit for Consumption. Experts Weigh in, by Rachel Rabkin Peachman, The New York Times, July 26, 2022

Drobne et al. used the terrestrial arthropod Porcellio scaber as a test organism for determining the cytotoxic effect of TiO₂ NPs (anatase). The animals were exposed to TiO₂ NPs of two different sizes (25 nm and 75 nm) in the concentration range 10–1000 μg TiO₂/g dry food for 3 to 14 days. No adverse effects, such as mortality, body weight changes or reduced feeding, were observed. In fact, quite the opposite, an enhanced feeding rate, food absorption efficiency and increase in catalase activity were observed. The intensity of these responses appeared to be time- but not dose-dependent. It should also be noted that the concentrations tested in this study were much higher than the predicted concentration (4.8 μg/g soil) at high emission scenario of nano-sized TiO₂. Using the same test organism another group showed that exposure to TiO₂ NPs induced destabilization of cell membrane in the epithelium of digestive glands isolated from exposed animals. They also showed that this effect can be observed after just 30 minutes of exposure.

Thanks to its rheological and optical properties, lithopone supplier 30% offers both technical and economic advantages in the substitution of titanium dioxide in different applications. Among these advantages, it has been observed that lithopone supplier 30% has algaecidal properties in paints, which gives greater protection to the coating. 

Understanding Anatase Titanium Dioxide

While IARC listed titanium dioxide as “possibly carcinogenic to humans,” they also add that “there is inadequate evidence in humans for the carcinogenicity of titanium dioxide.” Of the four human studies that they reviewed, only one showed a potential risk for occupational workers inhaling titanium dioxide particles and lung cancer, while the other three showed no risk for cancer at all. And it’s key to note that IARC did not assess the effects of titanium dioxide found in foods.

North America