Chloride process. This process requires a high titanium feedstock. Rutile is reacted with hydrochloric acid to produce titanium tetrachloride, which can be hydrolyzed with steam or oxidized with air to render the dioxide. A rutile form of titanium dioxide is obtained.

Asia

In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO₂ (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO₂ NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO₂ NPs conjugated with bacterial lipopolysaccharide, but not TiO₂ NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO₂ NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.

Titanium dioxide has been used as a bleaching and opacifying agent in porcelain enamels, giving them brightness, hardness, and acid resistance. In modern times it is used in cosmetics, such as in skin care products and sunscreen lotions, with claims that titanium dioxide protects the skin from ultraviolet radiation because of its property to absorb ultraviolet light.

Sunscreens made with mineral active ingredients, like titanium dioxide and zinc oxide, generally score well in EWG’s Guide to Sunscreens. They provide strong sun protection with few health concerns and don’t easily break down in the sun. 

Overall, CAS 13463-67-7 stands out as a reliable and trustworthy titanium dioxide factory that is committed to delivering top-quality products and services. With its focus on quality, sustainability, and innovation, the factory has established itself as a leader in the industry and a preferred partner for companies looking to source titanium dioxide for their dyes and pigments.

ZnSO4 + BaS + ZnS + BaSO4

The toxicity of P25TiO₂NPs under UV radiation could be even higher when combined with other usual components of sunscreens Indeed, Soler de la Vega et al. advise that combination with parabens increases the toxicity of the final cosmetic mixture [53].