Though the regulated use of titanium dioxide in food products is legal in the U.S. and Canada, it's banned in some other countries, notably throughout Europe. In May 2021, the European Food Safety Authority announced that titanium dioxide can no longer be considered safe as a food additive.
Prof Matthew Wright, both a member of the FAF Panel and chair of EFSA’s working group on E 171, said: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”
However, it’s also important to note that such adverse effects depend heavily on the form of the titanium dioxide. It can come down to characteristics like “particle shape, purity, surface charge, solubility, agglomeration rate, photo-activation, etc.”

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What is an exposure route?
Pigment grade titanium dioxide is produced at a much larger particle size than nano grade. It is used as a colourant to whiten and brighten product formulations. Nano grade titanium dioxide is manufactured into very fine (nano) particles and is transparent and colourless. It is commonly used in sunscreens to provide effective protection from potentially harmful UV rays.
In June 2022, Health Canada weighed in on the debate, releasing a report on the safety of titanium dioxide. Their expert panel reviewed toxicity studies, including ones involving genetic damage. The expert panel found that previous studies used different forms and properties of titanium dioxide and deliberately broke the material into smaller particles than what you would normally see in food.
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