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TiO2 is also used in the production of plastics, where it serves as a whitening agent and UV stabilizer. By incorporating TiO2 into plastic products, manufacturers can enhance their appearance, increase their lifespan, and improve their resistance to sunlight and weathering. Additionally, TiO2 helps prevent the degradation of plastic materials, ensuring that they retain their properties and performance over time.

According to the American Chemistry Council, titanium dioxide (TiO2) is an inorganic substance that's used as a white powder in a variety of industrial and consumer goods, including in sunscreen, cosmetics, toothpaste, paint, plastics, food and more.

Toxic effects of TiO₂ NPs on soil organisms

Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

Most notably, a European Food Safety Authority safety assessment published in May 2021 pointed to genotoxicity concerns, as suggested by previous research. Genotoxicity is the ability of chemicals to damage genetic information such as DNA, which may lead to cancer.

Fig. 2. SEM micrograph and EDS map of the same area of a vitaminB2@P25TiO₂NPs.

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Total zinc and barium sulphate

Over the last several years, nanoparticles have come under scrutiny for adverse health effects. Nanoparticles are ultrafine particles between 1 to 100 nanometers in diameter. (To put this in perspective, the average human hair is around 80,000 nanometers thick.) Because of their size, which can be engineered and manipulated at the atomic or molecular level, nanoparticles exhibit unique physical, chemical, and biological properties. Titanium dioxide is one of the most commonly produced nanoparticles in the world.

2.Inorganic white pigment. Widely used as a white pigment for plastics, paints and inks such as polyolefins, vinyl resins, ABS resins, polystyrene, polycarbonate, nylon and polyoxymethylene.

Prof Matthew Wright, both a member of the FAF Panel and chair of EFSA’s working group on E 171, said: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”