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Does It Cause Cancer?

CAS registration number: 1345-05-7

Overall, the use of titanium dioxide by manufacturers is essential for various industries, providing valuable properties and benefits for a wide range of products. As technology advances and new applications are discovered, the demand for titanium dioxide is expected to continue to grow. Manufacturers will need to adapt and innovate to meet the evolving needs of their customers while ensuring the safety and sustainability of their products.

Titanium dioxide is an inert earth mineral used as a thickening, opacifying, and sunscreen ingredient in cosmetics. It protects skin from UVA and UVB radiation and is considered non-risky in terms of of skin sensitivity. Because it is gentle, titanium dioxide is a great sunscreen active for sensitive, redness-prone skin. It’s great for use around the eyes, as it is highly unlikely to cause stinging.

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Currently, the development of TiO₂ memristors is associated with their use in modern highly technological applications, such as resistive random-access memory (RRAM), biohybrid systems, and sensors, as schematically shown in Figure 1A. In this mini-review, we briefly outline and summarize the key milestone achievements, as well as recent advances in the synthesis, fabrication, and application of TiO₂-based memristors. A special focus is placed on the relationships between the synthesis and deposition methods, the effects of post-synthesis treatment, and the resistive switching properties.

Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.