Although most studies to date show no harmful effects of titanium dioxide consumption, few long-term human studies are available. Therefore, more research is needed to better understand its role in human health (16Trusted Source, 18Trusted Source).
TiO2 comes in many different forms. However, only a few of these forms are considered food-grade (acceptable to be added to food). Many studies that raised concern about the safety of TiO2, including the concern for genotoxicity, used forms of TiO2 that are not considered acceptable for use in food and have different properties than food-grade TiO2. Other studies did use food-grade TiO2, but took steps to break the material down into smaller particles than what would normally be found in food.