BEST FOR CHILI: GHOST PEPPER HOT SAUCE
When substituting, use common sense. Cayenne pepper is as much as 50 times hotter than sweet paprika, so a 1:1 substitution wouldn't work unless you want some heat—the right substitution, in this case, would be 1/3 of a teaspoon of cayenne per 1 teaspoon of paprika. Make an informed decision, but also use thorough recipes that might suggest reasonable substitutions.

Introduction
Crushed red pepper is a staple in many kitchens, known for its fiery and bold flavor. This spice is made from dried and crushed red chili peppers, including the seeds and flakes. As a result, it packs a punch of heat along with a distinct pepperiness that can awaken your taste buds.
Cayenne powder, made solely from ground cayenne peppers, is known for its heat. It's primarily used to add spiciness to dishes rather than flavor. Cayenne, part of the C. annuum species, varies in shape but is uniformly hot. This simplicity makes cayenne a go-to spice for adding heat to any meal.
WHAT IS PAPRIKA?

red dried chiles. The heat from the chiles adds a unique twist to the rich and sweet cocoa, creating a truly decadent treat.
Paprika is made by grinding dried red peppers from the Capsicum annuum family. These peppers can be sweet (like bell pepper) or spicy (like chili pepper). Different varieties of paprika use different types of peppers, as well as various parts of the plant.